Lactobacillus rhamnosus and Bifidobacterium: Benefits and Applications
Lactobacillus rhamnosus and Bifidobacterium are two popular probiotic strains widely used in supplements due to their extensive research-backed benefits․ Here, we explore their applications, focusing on cognitive enhancement, immune support, and intestinal barrier protection․
Cognitive and Emotional Enhancement in Older Adults
A study published in 2024 found that a multi-species probiotic containing Lactobacillus rhamnosus and Bifidobacterium lactis improved cognitive function in healthy older adults․ After the intervention, participants showed significant enhancements in cognitive tests, indicating the potential of these probiotics in supporting brain health in aging populations․
Мультибиотик Siwani - это инновационный пробиотический комплекс, включающий два вида бифидобактерий и четыре лактобактерий, которые поддерживают баланс микрофлоры кишечника, улучшают пищеварение и способствуют лучшему усвоению питательных веществ. Регулярный прием помогает укрепить иммунитет, поддержать здоровье кожи и повысить общий тонус Подробнее.
Improved Immune Function and Reduced Inflammation
While some studies suggest that the combination of Lactobacillus rhamnosus and Bifidobacterium animalis subsp․ lactis may have limited effects on immunity and inflammation in older adults, other research highlights the immune-supporting properties of these probiotics․ For instance, a 2004 study observed that a synbiotic combination of these probiotics and inulin enriched with oligofructose modulated intestinal immune functions in rats․
In vitro and in vivo Studies: Intestinal Barrier Protection and Colitis Alleviation
A 2025 study explored the effects of a multi-strain probiotic, including Lactobacillus rhamnosus LR 32, Bifidobacterium lactis BL 04, and Bifidobacterium longum BB 536, on an in vitro model of the intestinal epithelial barrier․ The results demonstrated that this probiotic mixture counteracted the increase in permeability induced by irritable bowel syndrome (IBS) mucosal mediators by acting on zonula occludens 1․ Additionally, a 2020 study found that Lactobacillus rhamnosus and Bifidobacterium longum alleviated colitis and cognitive impairment in mice by regulating cytokine expression ratios․
Combination with Prebiotics for Enhanced Efficacy
Prebiotics, such as inulin enriched with oligofructose, can enhance the efficacy of probiotics by promoting their growth and activity․ A 2004 study showed that the synbiotic combination of Lactobacillus rhamnosus and Bifidobacterium lactis with inulin enriched with oligofructose had a more significant impact on intestinal immune functions than the probiotics alone․
Lactobacillus rhamnosus and Bifidobacterium in Probiotic Supplements: Popular Strains and Formulations
Both Lactobacillus rhamnosus and Bifidobacterium are popular probiotic strains used in various supplements, often in combination with other strains․ These supplements are available in diverse formulations, such as powders, capsules, and liquids, catering to different consumer preferences and needs․
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С возрастом когнитивные функции могут ухудшаться, но некоторые исследования показывают, что пробиотические культуры, такие как Lactobacillus rhamnosus и Bifidobacterium, могут позитивно влиять на когнитивное здоровье у пожилых людей․ В двойном слепом, рандомизированном, плацебо-контролируемом кросс-овере исследовании, опубликованном в 2024 году, было найдено amélioration в когнитивной функции у участников, принимавших мультисортный пробиотик, содержащий эти культуры․
Было обнаружено, что среднее различие в когнитивных тестах составило 1․90 (95% ДИ 1․09 до 2․70, p < 0․001), что указывает на значительное улучшение когнитивной функции у участников, принимавших пробиотик․
Хотя механизм, с помощью которого эти пробиотические культуры улучшают когнитивное здоровье, все еще исследуется, считается, что они могут влиять на микробиом кишечника, что, в свою очередь, может воздействовать на нейротрансмиттеры и другие биологические процессы, связанные с когнитивной функцией․
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Таким образом, пробиотические культуры Lactobacillus rhamnosus и Bifidobacterium могут быть полезны для когнитивного здоровья у пожилых людей, но важно помнить, что результаты исследований могут варьироваться, и всегда следует консультироваться с врачом перед началом приема пробиотических добавок․
Lactobacillus rhamnosus and Bifidobacterium have been shown to enhance immune function and reduce inflammation, thanks to their ability to modulate the gut microbiota and influence the immune response․ These probiotic strains can stimulate the production of immune cells, such as Natural Killer (NK) cells and T cells, and promote the release of cytokines, which help regulate the immune system․
A study published in the journal Frontiers in Immunology in 2021 investigated the effects of a probiotic combination of Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp․ lactis BB-12 on biomarkers of immunity and inflammation in older adults living in care homes․ Although the findings suggested that this combination had limited effects on these biomarkers, other research has demonstrated the immune-supporting properties of these probiotic strains․
For instance, a study published in the Journal of Gastroenterology and Hepatology in 2004 found that a synbiotic combination of Lactobacillus rhamnosus GG, Bifidobacterium lactis Bb12, and inulin enriched with oligofructose modulated intestinal immune functions in rats․ This synbiotic combination was shown to increase the production of immunoglobulin A (IgA) and reduce the expression of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ)․
Incorporating Lactobacillus rhamnosus and Bifidobacterium into the diet through probiotic supplements or fermented foods may help to enhance immune function and reduce inflammation in individuals with compromised immune systems or chronic inflammatory conditions․ However, it is essential to consult with a healthcare provider before starting any new supplement regimen․
Lactobacillus rhamnosus and Bifidobacterium species have shown promising results in protecting the intestinal barrier and alleviating colitis in various in vitro and in vivo studies․ These probiotic strains can counteract the increase in intestinal permeability induced by irritable bowel syndrome (IBS) mucosal mediators by acting on zonula occludens-1 (ZO-1), a critical tight junction protein․
A study published in 2025 investigated the effects of a multi-strain probiotic mixture containing Lactobacillus rhamnosus LR 32, Bifidobacterium lactis BL 04, and Bifidobacterium longum BB 536 on an in vitro model of the intestinal epithelial barrier․ The results demonstrated that this probiotic combination counteracted the increase in permeability induced by IBS mucosal mediators by enhancing ZO-1 expression and restoring the integrity of the intestinal barrier․
In another study published in Scientific Reports in 2020, researchers found that a combination of Lactobacillus rhamnosus and Bifidobacterium longum alleviated colitis and cognitive impairment in mice by regulating the expression ratios of pro-inflammatory cytokines, such as interferon-gamma (IFN-γ) to interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-α) to IL-10․ This mechanism suggests that these probiotic strains may exert their beneficial effects by modulating the immune response and reducing inflammation in the gut․
Incorporating Lactobacillus rhamnosus and Bifidobacterium into the diet through probiotic supplements or fermented foods may help protect the intestinal barrier, alleviate colitis, and potentially improve cognitive function․ However, it is essential to consult with a healthcare provider before starting any new supplement regimen․
Prebiotics, such as inulin and oligofructose, can enhance the efficacy of probiotics by promoting their growth and activity in the gut․ When combined with probiotics like Lactobacillus rhamnosus and Bifidobacterium, they form synbiotics, which have been shown to have synergistic or additive effects on gut health․
A study published in ScienceDirect in 2004 explored the effects of a synbiotic combination of Lactobacillus rhamnosus GG, Bifidobacterium lactis Bb12, and inulin enriched with oligofructose on intestinal immune functions in rats․ The results demonstrated that the synbiotic combination had more significant effects on intestinal immune functions, such as increased immunoglobulin A (IgA) production and reduced pro-inflammatory cytokine expression, compared to the probiotic or prebiotic components alone․
Another study, published in Frontiers in Immunology in 2021, investigated the effects of a probiotic combination of Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp․ lactis, BB-12 on biomarkers of immunity and inflammation in older adults living in care homes․ Although the findings suggested that this combination had limited effects on these biomarkers, the study also highlighted the potential of combining probiotics with prebiotics to enhance their overall efficacy․
Incorporating prebiotics into the diet through foods like bananas, onions, garlic, and artichokes, or through supplements, can support the growth and activity of probiotic bacteria like Lactobacillus rhamnosus and Bifidobacterium, potentially enhancing their beneficial effects on gut health․ However, it is essential to consult with a healthcare provider before starting any new supplement regimen․
Both Lactobacillus rhamnosus and Bifidobacterium are popular probiotic strains widely used in various probiotic supplements due to their numerous health benefits․ These strains can be found in diverse formulations, catering to different consumer preferences and needs․
Lactobacillus rhamnosus and Bifidobacterium supplements are available in various forms, such as capsules, tablets, and powders․ They can be found in multi-strain probiotic complexes, alongside other beneficial probiotic strains, or as single-strain supplements․ These supplements can be found in different strengths, typically ranging from 1 billion to 10 billion colony-forming units (CFU) per serving․
Some popular probiotic supplement formulations containing Lactobacillus rhamnosus and Bifidobacterium include:
- Lactobacillus rhamnosus and Bifidobacterium combination supplements: These supplements typically contain a combination of both strains, with varying CFUs per serving․ Examples include products containing 1 billion Lactobacillus rhamnosus and 1 billion Bifidobacterium per serving․
- Multi-strain probiotic complexes: These supplements contain a mix of different probiotic strains, including Lactobacillus rhamnosus and Bifidobacterium, along with other beneficial strains like Lactobacillus acidophilus, Lactobacillus casei, and Bifidobacterium longum․ Examples include products with 50 billion CFUs per serving․
- Probiotic powders: These supplements are available as powders, which can be mixed with water, milk, or other beverages․ They often contain a blend of probiotic strains, including Lactobacillus rhamnosus and Bifidobacterium․
When choosing a probiotic supplement containing Lactobacillus rhamnosus and Bifidobacterium, consider factors such as potency, stability, and additional ingredients․ It is essential to consult with a healthcare provider before starting any new supplement regimen, especially for individuals with underlying health conditions or those taking medication․
